Forced Degradation Studies of Ivabradine and In Silico Toxicology Predictions for Its New Designated Impurities

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Forced Degradation Studies of Ivabradine and In Silico Toxicology Predictions for Its New Designated Impurities

All activities should aim to eliminate genotoxic impurities and/or protect the API against degradation. There is a necessity to monitor impurities from all classification groups, hence ivabradine forced degradation studies were performed. Ivabradine was proved to be quite durable active substance, but still new and with insufficient stability data. Increased temperature, acid, base, oxidation r...

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ژورنال

عنوان ژورنال: Frontiers in Pharmacology

سال: 2016

ISSN: 1663-9812

DOI: 10.3389/fphar.2016.00117